National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances

摘要

The National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances (NAC/AEGL Committee ) is developing Acute Exposure Guideline Levels (AEGLs) on an on going basis to assist Federal and State agencies and private sector organizations with their needs for short-term hazardous chemical exposure information (one time only exposures during chemical emergency situations). The NAC/AEGL Committee has completed work on ``Proposed AEGLs'' for 12 chemicals. The purpose of today's notice is to solicit comments on proposed values and the accompanying scientific rationale for their development. More specifically, this notice solicits comments on the proposed AEGL values, the methodologies used to determine no-observed-adverse-effect- levels (NOAELs) or lowest-observed-adverse-effect-levels (LOAELs) for specific effects, the uncertainty factors selected for intraspecies and interspecies extrapolation, the uncertainity factors used to accommodate for sensitive or susceptible individuals in the human population, the use of modifying factors and the values applied, and other aspects related to the development of the AEGL values.