Prospective Grant of Exclusive License: Synthesis of Medical Opiate Compounds

摘要

This is notice, in accordance with 35 U.S.C. 209(c)(1) and 37 CFR 404.7(a)(1)(i), that the National Institutes of Health (NIH), Department of Health and Human Services, is contemplating the grant of an exclusive license in the United States to practice the invention embodied in: U.S. Patent No. 4,410,700, issued October 18, 1983 (U.S. Patent Application Serial No. 06/265,469, filed May 20, 1981), entitled ``Preparation of Chiral 1-Benzyl-1,2,3,4-Tetrahydroisoquinolines by Optical Resolution''; U.S. Patent No. 4,521,601, issued June 4, 1985 (U.S. Patent Application Serial No. 06/477,970, filed March 23, 1983), entitled ``Practical Total Synthesis Unnatural Enantiomers of Opium Derived Morphinans''; U.S. Patent No. 4,556,712, issued December 3, 1985 (U.S. Patent Application Serial No. 06/476,830, filed March 18, 1983), entitled ``Preparation and Racemization of Chiral 1-Benzyl- 1,2,3,4-Tetrahydroisoquinolines''; U.S. Patent No. 4,613,668, issued September 23, 1986 (U.S. Patent Application Serial No. 06/564,515, filed December 22, 1983), entitled ``Short Total Synthesis of Morphinan Compounds Which Uses Cyclization of a Cycloalkylcarbonyl Compound Selected from Cyclopropylcarbonyl Cyc