Government-Owned Inventions; Availability for Licensing

الملخص

The invention listed below is owned by an agency of the U.S. Government and is available for licensing in the U.S. (and in foreign markets) in accordance with 35 U.S.C. 207 to achieve expeditious commercialization of results of federally funded research and development. U.S. Patent Application Number 07/941,371, filed September 3, 1992, and entitled ``Self-Assembling Recombinant Papillomavirus Capsid Proteins''--The invention described in this application and its continuation application (U.S. Patent Application Number 08/032,869, filed March 16, 1993) is an enzyme-linked immunosorbent assay (ELISA) to detect humoral immunity response to papillomavirus infection in humans and other vertebrates. Assays have thus far been produced based upon serum immunoglobulin recognition of conformation epitopes of papillomavirus virion proteins on purified virus-like particles for HPV16, which is the HPV type most frequently found in cervical cancer. Assays for other high-risk cervical cancer HPV types (HPV18, HPV31, and HPV45) and for low-risk genital HPV types (HPV6 and HPV11) are under development using the same technology. The ELISA test for the genital HPV types may be useful as an adjunct t