Regulacje i polityka gospodarcza · 29.10.2008

Ethylene Oxide; Preliminary Determination to Terminate Special Review

This notice announces EPA's preliminary determination to terminate the Special Review of ethylene oxide (ETO). On January 27, 1978, EPA initiated Special Review based on developmental toxicity, mutagenicity, and neurotoxic effects in workers (43 FR 3801). In the early 1980s, the carcinogenicity of ETO became of concern and was added to the Special Review. Since the initiation of the Special Review, additional data and more comprehensive reviews of potential risks associated with ETO exposure have been completed, including those described in the 2006 Tolerance Reassessment and Risk Management Decision (TRED) (http://www.epa.gov/oppsrrd1/REDs/ethylene_oxide_ tred.pdf) and the 2008 Reregistration Eligibility Decision (RED) (http://www.epa.gov/oppsrrd1//REDs/ethylene-oxide-red.pdf) for ETO. In the 2008 RED, the Agency addressed occupational risk concerns that were the focus of the Special Review. During the reregistration process EPA conducted a public, intensive review of ETO risks and benefits to determine whether or not ETO registrations meet the Federal Insecticide, Fungicide, Rodenticide Act (FIFRA) standard for registration. The Agency determined that the benefits of ETO use outw