Regulacje i polityka gospodarcza · 13/12/1999

Summary of the U.S. EPA Workshop on the Relationship Between Exposure Duration and Toxicity

The notice announces the availability of a final report, Summary of the U.S. EPA Workshop on the Relationship Between Exposure Duration and Toxicity (EPA/600/R-99/081, September 1999). This report was prepared by Eastern Research Group, Inc. (ERG), for the U.S. Environmental Protection Agency's (EPA) National Center for Environmental Assessment (NCEA), within the Office of Research and Development (ORD). Current risk assessment procedures are typically based on overall daily exposure levels and tend to emphasize effects resulting from continuous exposure over a lifetime. Scientists now realize that exposures are more likely to be experienced as bursts or spikes, or intermittent exposures of varying levels. EPA's Risk Assessment forum is beginning to examine how dose-duration relationships are or can be incorporated into the risk assessment process for less-than-lifetime exposures. As part of this effort, the Forum and the Harvard School of Public Health, held a workshop on August 5-6, 1998, to discuss the current understanding of dose-duration relationships, the approaches that can be used in their modeling, the inclusion of these relationships in risk assessment, and future direct